Enigma of Sépia Tier List and Reroll Guide: April 2025 for Best Units

Enigma of Sépia lets you save the world from destruction. But remember, the whole gameplay here will be testing your limits with many challenges, so having the best heroes by your side can save your day. Now, if you want to learn who are the best heroes and how to earn them, this is your Enigma of Sépia tier list and reroll guide for it. Play Enigma of Sépia on PC with LDPlayer, and let’s start.

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All Characters Ranked in the Enigma of Sépia Tier List 

Here is a list of all the heroes under their specific strength levels.

SS-Tier Characters in the Enigma of Sépia Tier List 

SS-ranked heroes are exceptional, powerful heroes who show no weaknesses. They are unbeatable and have the most overpowered strength levels and skills than the others.

Chronis

• Role: Debuff Support / Sustained DPS
• Strength: She buffs allied units and applies curses to enemies, enhancing team performance.
• Weakness: Less effective as a standalone damage dealer compared to pure DPS units.
• Best Strategies: A must-have for team synergy. Use her to amplify damage dealers and control enemy effectiveness in prolonged fights.

Sanguina

• Role: Single-Target DPS / Crowd Control
• Strength: Inflicts the highest single-target damage in the game and excels at crowd control with bleed and curse effects. She’s noted as an SP rarity character.
• Weakness: Lacks AoE damage, making her less effective against groups without support.
• Best Strategies: Essential for mid- and late-game, particularly in boss fights or PvP. Pair with AoE damage dealers to compensate for her single-target focus.

Sepia 

• Role: Versatile Leader / Support
• Strength: From the Legend Guild, she handles multiple enemies with AoE capabilities and provides team-wide buffs. Noted for unique, well-rounded skills.
• Weakness: Her broad utility might dilute specialization.
• Best Strategies: Use as a team leader to boost overall performance. Effective in various game modes with the right build, especially for new players via newbie events.

Satoria

• Role: AoE Magical DPS
• Strength: Deals AoE magical damage and reduces enemy speed with an “Azure” effect.
• Weakness: Not explicitly stated, but AoE focus might mean lower single-target burst compared to Sanguina.
• Best Strategies: Complements single-target units like Sanguina. Ideal for clearing enemy waves and controlling the battle pace.

S-Tier Characters in the Enigma of Sépia Tier List 

S-tier characters are also called the most powerful. They have a similar level of versatility, just like the heroes who are in the SS rank.

Vespera

• Role: TBD
• Strength: High-performing unit, likely a strong damage dealer or support based on tier placement.
• Weakness: TBD
• Best Strategies: Prioritize for team composition.

Erenor

• Role: TBD
• Strength: Reliable in most scenarios, per S-tier norms.
• Weakness: TBD
• Best Strategies: Use as a flexible unit, pending more specifics.

Yukari

• Role: TBD
• Strength: Valued for solid damage output or utility, typical of S-tier.
• Weakness: TBD
• Best Strategies: Include balanced teams, though the exact role is unclear.

Nova 

• Role: TBD
• Strength: Strong for free-to-play players at 10+ stars, suggesting good scalability.
• Weakness: TBD
• Best Strategies: Build to high stars for mid- to late-game viability.

Lena Frost 

• Role: TBD
• Strength: High utility or damage, per S-tier ranking.
• Weakness: TBD
• Best Strategies: Incorporate into core teams, role TBD.

Little Rasi

• Role: Bleed Stacker / DPS
• Strength: Stacks bleed debuffs for burst damage setups.
• Weakness: TBD
• Best Strategies: Pair with burst units like Eclipsea for one-shot PvE or boss lineups.

Eclipsea

• Role: Bleed Stacker / Burst DPS
• Strength: Core unit for bleed-based lineups, deals massive burst damage with Rage skill.
• Weakness: TBD
• Best Strategies: Use as a core with bleed stackers (e.g., Little Rasi) for PvE and boss fights.

Carmilla

• Role: TBD
• Strength: Likely a standout SSR+ unit.
• Weakness: TBD
• Best Strategies: High priority for investment, role unclear.

Lumina

• Role: Unknown (Insufficient specific data)
• Strength: Versatile or strong in specific content, per S-tier.
• Weakness: TBD
• Best Strategies: Flexible placement, specifics lacking.

A-Tier Characters in the Enigma of Sépia Tier List

You get the best heroes here. They are also quite powerful like those who are in the SS and S ranks. The only difference is that they have a slightly under performance than those who are in the tier SS and S ranks.

• Sylphyra: Decent damage or support, specifics unclear.
• Sandra: Reliable mid-tier damage or utility unit.
• Naldra: Functional as a mid-tier filler unit.
• Morgana: Strong synergy partner, excels in support roles.
• Giselle: Arguably the best SSR+ for PvE and PvP, offering versatility.
• Elysia: Offers situational effectiveness in the right team.
• Celestia: Provides balanced skills, likely a hybrid damage/support unit.
• Aqua Sera: Deals AoE damage with potential support utility.

B-Tier Characters in the Enigma of Sépia Tier List

You get the heroes for the Enigma of Sépia beginners here. They have some sort of weaknesses as well, but when it takes it as a whole, they have some good stats and bonuses that can make them some good heroes to rely on.

• Scientia: Healer or utility, effective in mid-tier teams.
• Nora Zorana: Inspired by Zoro from One Piece. Chains fast attacks with decent durability.
• Mentora: Healer, best in backline support roles.
• Ivy Lynn: Mecha-themed utility.
• Denise: Chainsaw-wielding devil hunter, solid in niche teams.
• Crimson: Average damage dealer, situational use.
• Caelestis: Decent support or damage in specific setups.
• Bipolaris: Inspired by Ken Kaneki from Tokyo Ghoul. Unique but average skills.

C-Tier Characters in the Enigma of Sépia Tier List

C-tier characters are the above-average heroes. There are both strengths and weaknesses combined with these heroes, and they will be mostly situational performers.

• Sylvia: Applies bleed, minor utility in specific teams.
• Ginara: Low damage output, early-game use only.
• Eliza Thorn: Niche use, underwhelming overall.
• Eldwyn: Stacks bleed debuffs, situational in bleed lineups.
• Dr. Lorena: Sword user with limited effectiveness.
• Ayame: Basic unit, minimal impact.
• Aurora: Early-game filler, lacks staying power.
• Alfyria: Basic functionality, quickly outclassed.

D-Tier Characters in the Enigma of Sépia Tier List

These are the weakest, and none of them can be recommended for your gameplay.

• Yurina: Basic unit, easily replaced.
• Royelle: Low-tier damage or support.
• Mirage: Weakest tier, negligible impact.
• Lyra: Minimal utility, early-game only.
• Little Sai: Inspired by Sasuke from Naruto. It is viable at 10+ stars for free-to-play, otherwise weak.
• Levia: Poor performance, not worth investment.
• Cheshire: Limited use, lacks strength.

Enigma of Sépia Reroll Guide 

To collect these heroes, you have to perform an Enigma of Sépia reroll, as that is how you can pull out the heroes for a battle. And this is how you can do it.

• Log into the game and play as a guest.
• Complete the tutorial until you get your first 10 summons.
• Check if you have earned a desired character or not. If not, go back to the profile and then tap the Switch Account option.
• Now login back to the game with a new server or again login as a guest
• Create your new game account and then proceed to reroll again.

As you can see, doing a back-and-forth reroll until you get a desired hero takes so much time. So, if you want to speed up the process, there is a perfect way to do so with LDPlayer. The emulator helps you to perform multiple rerolls at once and here is how it is going to be done.

• Install LDPlayer
• Download the game, and keep it from being played.
• Go to the emulator menu and then click LDMutiplayer.
• Create several instances of the game as much as you want
• Now, sync all instances through the Synchronizer tool. So, every action you perform in one instance will be applied to all.
• Go for an Enigma of Sépia reroll.

Remember that the amount of instances you create should be based on the storage capacity of the PC. Because some PCs would not be able to handle more than four as each instance takes up a certain memory from the device.

PS: This tier list is created based on our personal opinions of the heroes. So, feel free to experiment with the heroes to see who will be the best on your handle.

Conclusion

So, that is all for the Enigma of Sépia tier list and reroll guide, and here we bring the SS to the D-ranked heroes, so now you know who to rely on. Make sure to go with the tier S ranks as much as you can because they can always save your day.